Exemplis Discimus 2009, 153(4):259-262

Proin justo lacus, suscipit at, imperdiet a, sollicitudin vel, tellus.

Goror Gregorya,b, Janos Drackonb, Ghent Amaviaa, Abia Leatsb,c, Eera Corshd
a 1st Clinic of Social Medicine, Toydaria Teaching Hospital, Republic of Sullust
b Department of Pediatric Surgery, Lahara Faculty Hospital, Republic of Kamino
c Department of Pharmacognosy, University Hospital of Bothan, Republic of Yavin
d Department of Orthopaedics, University of Naboo, Republic of Anoat

Background: Donec eros augue, posuere et, aliquam sed, tristique et, leo. Duis justo nibh, ultrices sit amet, molestie at, tristique in, augue. Proin sit amet tellus tincidunt nibh mollis tempor. Proin ligula lacus, sollicitudin in, euismod quis, elementum vitae, turpis. Nam quis odio pellentesque metus scelerisque mollis. Morbi tellus justo, suscipit sit amet, egestas a, consectetuer eu, ligula. Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Curabitur ipsum eros, imperdiet et, aliquet quis, malesuada quis, nisl.

Aim: Aliquam auctor, nibh vel congue congue, velit mi vulputate libero, vitae fringilla massa ipsum id risus. Nulla lobortis, orci in consequat varius, felis purus condimentum est, non blandit magna dui vel orci..

Method: Fusce arcu quam, rhoncus vel, ultrices sed, volutpat a, odio. Pellentesque lorem metus, sodales non, pellentesque ut, facilisis at, ante. Nullam eget justo in quam condimentum feugiat. Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Mauris massa elit, tincidunt vitae, consequat ut, accumsan non, pede. Aliquam sit amet turpis sollicitudin nunc adipiscing ornare. Sed magna felis, viverra in, pharetra at, sodales eu, ante. Proin arcu velit, tristique vitae, rhoncus sed, fermentum eget, risus.

Keywords: Aenean nisi, Sed et nulla, Maecenas eu lorem, Aenean nec nibh, Suspendisse volutpat, Etiam gravida, Aliquam ac diam

Received: July 10, 2009; Accepted: November 11, 2009; Published: December 1, 2009 

Open full article

References

  1. Bajgar J. Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 2004; 38: 151216. Go to original source... Go to PubMed...
  2. Zdarova Karasova J, Bajgar J, Novotny L, Kuca K. Is a high dose of Huperzine A really suitable for pretreatment against high doses of soman? J Appl Biomed 2009; 7: 9399.
  3. Marrs TC. Organophosphate poisoning. Pharmacol Ther 1993; 58: 5166. Go to original source... Go to PubMed...
  4. Kuca K, Kassa J. In vitro reactivation of acetylcholinesterase using of the oxime K027. Vet Hum Toxicol 2004; 46: 1518.
  5. Musilek K, Kuca K, Jun D, Dolezal M. Progress in synthesis of new acetylcholinesterase reactivators during the period 19902004. Curr Org Chem 2007; 11: 229238. Go to original source...
  6. Kovarik Z, Calic M, Vrdoljak AL, Radic B. Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate- poisoned mice. J Mol Neurosci 2006; 30: 113114. Go to original source... Go to PubMed...
  7. Petroianu GA, Arafat K, Nurulain SM, Kuca K, Kassa J. In vitro oxime reactivation of red blood cell acetylcholinesterase inhibitied by methyl-paraoxon. J Appl Toxicol 2007; 27: 168175. Go to original source... Go to PubMed...
  8. Petroianu GA, Hasan MY, Nurulain SM, Nagelkerke N, Kassa J, Kuca K. New K-oximes (K-27and K-48) in comparison with obidoxime (LuH-6), HI-6, trimedoxime (TMB-4) and pralidoxime (2-PAM): survival in rats exposed ip to the organophosphate paraoxon. Toxicol Mech Meth 2007; 17: 401408. Go to original source... Go to PubMed...
  9. Petroianu GA, Nurulain SM, Nagelkerke N, Shafiullah M, Kassa J, Kuca K. Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon. J Appl Toxicol 2007; 27: 453457. Go to original source... Go to PubMed...
  10. Pohanka M, Jun D, Kuca K. Photometric microplate assay for estimation of paraoxon inhibited acetylcholinesterase reactivation efficacy. J Enzyme Inhib Med Chem 2008; 23: 781784. Go to original source... Go to PubMed...
  11. El-Naggar AR, Abdalla MS, El-Sebaey AS, Badawy SM. Clinical findings and cholinesterase levels in children of organophosphates and carbamates poisoning. Eur J Pediatr 2009; 168: 951956. Go to original source... Go to PubMed...
  12. Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M. Synthesis of the novel series of asymmetrical bispyridinium compounds bearing xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. J Enzyme Inhib Med Chem 2007; 22: 425432. Go to original source... Go to PubMed...
  13. Jun D, Stodulka P, Kuca K, Koleckar V, Dolezal B, Simon P, Veverka M. HPLC analysis of HI-6 dichloride and dimethanesulfonate antidotes against nerve agents and organophosphorus pesticides. Anal Lett 2007; 40: 27832787. Go to original source... Go to PubMed...
  14. Jun D, Stodulka P, Kuca K, Koleckar V, Dolezal B, Simon P,Veverka M. TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate. J Chrom Sci 2008; 46: 316319. Go to original source...
  15. Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V, Dolezal M. Synthesis of Monooxime-Monocarbamoyl Bispyridinium Compounds bearing (E)-but-2-ene Linker and Evaluation of their Reactivation Activity against Tabun and Paraoxon-Inhibited Acetylcholinesterase. J Enzyme Inhib Med Chem 2008; 23: 7076. Go to original source... Go to PubMed...
  16. Novotny L, Karasova J, Kuca K, Bajgar J, Misik J. Influence of different wals of euthanasisa on the aktivity of cholinesterases in the rat. J Appl Biomed 2009; 7: 115118.
  17. Bajgar J, Kuca K, Jun D, Bartosova L, Fusek J. Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/ nerve agents. Curr Drug Metab 2007; 8: 803809. Go to original source... Go to PubMed...
  18. Li Y, Sun C, Qiu Z, Ma S, Yu X, Wang Z, Eddleston M. Clinical toxicology in China: current situation and future development. Clin Toxicol (Phila) 2009; 47: 263269. Go to original source... Go to PubMed...
  19. Wickramasinghe K, Steele P, Dawson A, Dharmaratne D, Gunawardena A, Senarathna L, de Siva D, Wijayaweera K, Eddleston M, Konradsen F. Cost to government health-care services of treating acute self-poisonings in a rural district in Sri Lanka. Bull World Health Organ 2009; 87: 180185. Go to original source... Go to PubMed...
  20. Eddleston M, Buckley NA, Eyer P, Dawson AH: Management of acute organophosphorus pesticide poisoning. Lancet 2008; 371: 597607. Go to original source...
  21. Lorke DE, Hasan MY, Arafat K, Kuca K, Musilek K, Schmitt A, Petroianu GA. In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate. J Appl Toxicol 2008; 28: 422429. Go to original source... Go to PubMed...
  22. Lorke DE, Hasan MY, Nurulain SM, Sheen R, Kuca K, Petroianu GA. Entry of two new asymmetric bispyridinium oximes (K-27 and K-48) into the brain: comparison with obidoxime. J Applied Toxicol 2007; 27: 482490. Go to original source... Go to PubMed...
  23. Lorke DE, Nurulain SM, Hasan MY, Kuca K, Musilek K, Petroianu GA. Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: In vivo efficacy to protect from diisopropylfluorophosphate (DFP) toxicity. J Appl Toxicol 2008; 28: 920928. Go to original source... Go to PubMed...
  24. Gholivand K, Mojahed F, Salehi M, Naderi-Manesh H, Khajeh K. Synthesis, characterization and inhibitory potency of two oxono and thiono analogues of phosphoramidate compounds on acetylcholinesterase. J Enzyme Inhib Med Chem 2006; 21: 521525. Go to original source... Go to PubMed...
  25. Bartosova L, Kuca K, Kunesova G, Jun D. The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure. Neurotox Res 2006; 9: 291296. Go to original source... Go to PubMed...
  26. Kuca K, Kassa J. Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent. Hum Exp Toxicol. 2004; 23: 167171. Go to original source... Go to PubMed...
  27. Kassa J, Jun D, Kuca K. A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin and tabun-poisoned rats. J Enzyme Inhib Med Chem 2007; 22: 297300. Go to original source... Go to PubMed...
  28. Kassa J, Karasova J, Bajgar J, Kuca K, Musilek K. A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice. J Enzyme Inhib Med Chem 2008; 23: 776780. Go to original source... Go to PubMed...
  29. Lundy PM, Raveh L, Amitai G. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev 2006; 25: 23143. Go to original source... Go to PubMed...
  30. Kuca K, Jun D, Bajgar J. Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications. Curr Pharm Des 2007; 13: 34453452. Go to original source... Go to PubMed...
  31. Kuca K, Racakova V, Jun D. Relationship between structure of chlorpyrifos-inhibited acetylcholinesterase reactivators and their biological activity. Chem Pap 2007; 61: 256261. Go to original source...
  32. Musilek K, Jun D, Cabal J, Kassa J, Gunn-Moore F, Kuca K. Design of a potent reactivator of tabun-inhibited acetylcholinesterase Synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4- (4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). J Med Chem 2007; 50: 55145518. Go to original source... Go to PubMed...
  33. Musilek K, Kuca K, Jun D, Dolezal M. In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase. J Appl Biomed 2007; 5: 2530.
  34. Kim TH, Kuca K, Jun D, Jung YS. Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators. Bioorg Med Chem Lett 2005; 15: 29142917. Go to original source...
  35. Kim TH, Oh KA, Park NJ, Lim YJ, Yum EK, Jung YS. Reactivation study of pyridinium oximes for acetylcholinesterases inhibited by paraoxon or DFP. J Appl Biomed 2006; 4: 6772. Go to PubMed...
  36. Kovacevic V, Maksimovic M, Deljac V, Binenfeld Z. The efficacy of 1,1-(1,4-buten)-bis-(4-hydroxyiminomethyl-pyridinium) dibromide in the treatment of organophosphate poisoning. Acta Pharm 1989; 39: 167170.
  37. Kovacevic V, Maksimovic M, Pantelic D, Vojvodic V, Binenfeld Z. Protective and reactivating effects of HI-6 PAM-2 mixture in rats with nerve chemical warfare agents (nerve CWA). Acta Pharm 1989; 39: 161165.
  38. Worek F, Aurbek N, Thiermann H. Reactivation of organophosphate- inhibited human AChE by combinations of obidoxime and HI 6 in vitro. J Appl Toxicol 2007; 27: 582588. Go to original source... Go to PubMed...

Return to the content